Margot Robbie, Sheryl Lee Ralph and more actors react to SAG-AFTRA strike

Fran Drescher, president of the Screen Actors Guild-American Federation of Television and Radio Artists (SAG-AFTRA) announced during a press conference in Los Angeles on Thursday that the union representing Hollywood actors will go on strike.

"It's official @sagaftra has voted to strike. We will be joining the @wgawest @wgaeast on the picket lines starting tomorrow," Yvette Nicole Brown wrote in a post on her Instagram page on Thursday as news of the strike became official.

She added, "In preparation we all got together last week to create our signs. I was on sticks! When you're out there without a splinter thanks to the perfectly placed duct tape, think of ya girl! #UnionStrong."

The official strike declaration comes after SAG-AFTRA's negotiating committee's talks with major studios and streaming services about a new contract failed, even after the original deadline to make a deal was extended by weeks and a federal mediator got involved.

The strike is set to go into effect at midnight PT Thursday night, but many actors have spoken about the impact it will have before it officially commenced.

On the red carpet of the "Oppenheimer" premiere in London - moments before the cast walked out in solidarity of the strike - Matt Damon told Deadline that a strike will impact his new production company that he started with Ben Affleck.

"It's going to be tough for the actors, for 160,000 actors. Nobody wants a work stoppage," Damon added. "But if our leadership is saying that the deal isn't fair then we've got to hold strong until we get a deal that's fair for working actors."