Andie MacDowell says daughter Margaret Qualley pushed her to leave LA, live a quiet life in South Carolina

The actress shares three children with her ex-husband, Paul Qualley - daughters Margaret and Rainey, along with their son Justin. 

MacDowell said her daughter Margaret was the inspiration behind the move and shift in mindset. 

"Margaret really was kinda telling me I was supposed to be having the time of my life, but I wasn't," she told Barrymore. "But now I am. I'm having the time of my life now. It's really good."

Barrymore, who is a mom of two, asked MacDowell if she'd be willing to walk her through that process once she becomes an empty-nester. 

"I'll tell you what not to do," MacDowell said. "Come to me, because I have all the information on how not to waste your time. How to get on with it and have a good time. I'll tell you."

During her appearance, MacDowell also revealed that she is battling a painful neuromuscular disorder.

"I have piriformis syndrome, so it's a muscle that kind of clamps down on my sciatic nerve, and it was shooting down my leg," MacDowell revealed.

"I thought I was going to have hip replacement - thank God, my hips are fine," she said.

Piriformis syndrome occurs when your piriformis muscle compresses your sciatic nerve and results in inflammation. It can cause pain or numbness in your buttocks and down the back of your leg. It can happen on one side of your body or both, according to the Cleveland Clinic. 

Fox News Digital's Stephanie Giang-Paunon contributed to this post.